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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOPBP1
All Species:
15.15
Human Site:
T1109
Identified Species:
47.62
UniProt:
Q92547
Number Species:
7
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92547
NP_008958
1522
170679
T1109
A
S
S
T
P
D
S
T
R
S
A
R
S
G
R
Chimpanzee
Pan troglodytes
XP_516761
1587
177009
S1174
A
S
S
T
P
D
S
S
R
S
A
R
S
G
R
Rhesus Macaque
Macaca mulatta
XP_001112636
1622
181547
T1209
A
S
S
T
P
D
S
T
R
S
A
R
S
G
R
Dog
Lupus familis
XP_534266
1697
189421
T1284
A
S
S
T
P
D
S
T
R
S
A
R
S
G
R
Cat
Felis silvestris
Mouse
Mus musculus
Q6ZQF0
1515
168842
A1111
A
S
S
T
P
D
S
A
R
S
V
R
S
G
R
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524909
1425
158421
T1038
P
T
R
T
T
Q
A
T
K
L
N
F
D
R
S
Honey Bee
Apis mellifera
XP_394416
1192
134009
L805
L
S
E
L
K
K
Q
L
W
Q
K
L
K
Q
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_788169
651
72132
E264
K
R
G
P
E
K
K
E
S
D
A
G
K
D
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.4
91.8
81.1
N.A.
76.8
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
25.2
21.1
N.A.
21.4
Protein Similarity:
100
95.6
93.1
85
N.A.
85.7
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
44.1
38.5
N.A.
30
P-Site Identity:
100
93.3
100
100
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
6.6
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
33.3
13.3
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
63
0
0
0
0
0
13
13
0
0
63
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
63
0
0
0
13
0
0
13
13
0
% D
% Glu:
0
0
13
0
13
0
0
13
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
13
0
0
0
% F
% Gly:
0
0
13
0
0
0
0
0
0
0
0
13
0
63
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
13
0
0
0
13
25
13
0
13
0
13
0
25
0
0
% K
% Leu:
13
0
0
13
0
0
0
13
0
13
0
13
0
0
13
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
13
0
0
0
0
% N
% Pro:
13
0
0
13
63
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
13
13
0
0
13
0
0
0
13
13
% Q
% Arg:
0
13
13
0
0
0
0
0
63
0
0
63
0
13
63
% R
% Ser:
0
75
63
0
0
0
63
13
13
63
0
0
63
0
13
% S
% Thr:
0
13
0
75
13
0
0
50
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
13
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
13
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _